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PARS‑TRODAT® Kit

 Sterile, NonPyrogen Lyophilized Powder

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SPECT Imaging
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Diagnostic
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About the Product

PARS‑TRODAT is a sterile, non‑pyrogen lyophilized radiopharmaceutical kit designed for the preparation of 99mTc‑Trodat for SPECT brain imaging. Each vial contains 33 µg of Trodat as a sterile, non‑pyrogen lyophilized powder, and after radiolabeling, it is used for intravenous administration. This radiopharmaceutical binds to the dopamine transporter (DAT) in the striatum, enabling assessment of dopaminergic neuron function. Reduced uptake is typically indicative of dopaminergic neuron degeneration, a condition observed in Parkinson’s disease.

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Applications
  • Assistance in the diagnosis of Parkinson’s disease
  • Differentiation of Parkinson’s disease from essential tremor
  • Evaluation of movement disorders associated with dopaminergic system decline
  • Assessment of the extent and progression of neuronal degeneration
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Mechanism of Action

99mTc‑Trodat binds to the dopamine transporter (DAT) located at the presynaptic nerve terminals of the striatum. In neurodegenerative disorders, the number of these transporters is significantly reduced. The binding of this radiopharmaceutical to DAT enables visual assessment of the integrity and health of the dopaminergic system, helping the physician to provide a more accurate diagnosis.

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Preparation and Administration

Note: This pharmaceutical product is intended solely for use in nuclear medicine facilities by personnel experienced in handling radiopharmaceuticals.

The PARS‑TRODAT® kit is radiolabeled with sterile, non‑pyrogen sodium pertechnetate injection (Na99mTcO₄), eluted from a 99Mo/99mTc generator, at the activity prescribed by the physician, and is then prepared for intravenous administration as a single dose.

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Box Contents

Each box contains one instruction leaflet and one Trodat kit vial, along with one label specifically for the radiolabeling procedure.

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Composition

Trodat (33 µg)

Stannous Chloride Dihydrate

Tricine

Mannitol

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Storage Conditions
  • Store the PARS‑TRODAT® kit in a freezer (-8°C to -20°C) and protected from light. The cold chain must be maintained under all circumstances.
  • After radiolabeling, 99mTc‑Trodat must be used within 4 hours and stored below 25°C.
  • The PARS‑TRODAT® kit should not be used after the expiration date.
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