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PARS-TRODAT

TRODAT radiopharmaceutical kit after labeling with Tc-99m is used for imaging, diagnosis and staging of Parkinson’s disease.

Parkinson’s disease (PD) is a common progressive neurological disorder (after Alzheimer’s) caused by neurodegeneration. The most common symptoms are tremors, slowness of movement and muscle stiffness. Parkinson’s mainly affects dopamine-producing neurons in a specific area of the brain. Dopamine plays an important role in regulating body movement.

The Tc-99m-TRODAT radiopharmaceutical binds intelligently and selectively to dopamine transporters in the brain, and this is useful for assessing the loss of dopamine neurons in Parkinson’s disease and other neurodegenerative diseases.

• Add 0.5 mL 0.9% saline in an evacuated vial, and allow the mixture to preincubate for 5 min.
• Add aseptically sterile and non-pyrogenic solution of ^99mTcO₄^– (10 – 40 mCi) in 0.5 mL saline.
•  Shake the contents of the vial slowly for a few seconds.
•  Heat the vial for 30 minutes at 95 °C.
•  Wait 30 minutes for cooling to room temperature.
• The reconstituted solution is stable for 6 hrs.

•  Store the kit      – 20 °C, keep away    from light and humidit
•  Store the reconstituted kit     15 – 25 °C