Fibroblast activation protein (FAP) plays an important role in changing the situation of the tissue and helps the tumor cells to attack the surrounding tissues. FAP receptor-defined tumors and cancer-associated fibroblasts (CAFs) play an important role in various aspects of malignant tumors such as migration, metastasis, resistance to chemotherapy, and immunosuppression. Therefore, targeting these cells might be useful for both imaging and treatment purposes. This receptor is expressed in various cancers such as bone, brain, breast, colon, esophagus, stomach, liver, lung, mouth, ovary, pancreas, kidney, etc.
The PARS-GALUFAPI diagnostic radiopharmaceutical kit, which is labeled with Ga-68, identifies FAP receptors intelligently and selectively, and detects tumors in which this type of receptor is expressed and provides high quality images from the patient using a PET scan device.